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- Boone M, Wang L, Lawrence R, Frost A, Walter P, Schoof M. A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation. eLife 11:e76171, 2022
(PMID: 35416150) (PDF) - Yildirim Z, Baboo S, Hamid SM, Dogan AE, Tufanli O, Robichaud S, Emerton C, Diedrich JK, Vatandaslar H, Nikolos F, Gu Y, Iwawaki T, Tarling E, Ouimet M, Nelson DL, Yates JR 3rd, Walter P, Erbay E. Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression. EMBO Mol Med 14(4):e15344, 2022
(PMID: 35191199) (PDF) - Le Thomas A, Ferri E, Marsters S, Harnoss JM, Lawrence DA, Zuazo-Gaztelu I, Modrusan Z, Chan S, Solon M, Chalouni C, Li W, Koeppen H, Rudolph J, Wang W, Wu TD, Walter P, Ashkenazi A. Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α. Nat Comms DOI: 10.1038/s41467-021-27597-7, 2021
(PMID: not available) (PDF) - Belyy V, Zuazo-Gaztelu I, Alamban A, Ashkenazi A, Walter P. Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers. bioRxiv https://www.biorxiv.org/content/10.1101/2021.09.29.462487v1, 2021
(PMID: not available) (PDF) - Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter P. Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Comms (2021) 12:7103, 2021
(PMID: not available) (PDF) - Tran NH *, Carter SD *, De Mazière A, Ashkenazi A, Klumperman J, Walter P *, Jensen GJ *. The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes. Science 374:52-57, 2021
(PMID: 34591618) (PDF) - Wang L, Toutkoushian H, Belyy V, Kokontis C, Walter P. Conserved structural elements specialize ATAD1 as a membrane protein extraction machine. bioRxiv DOI: 10.1101/2021.09.24.461712, 2021
(PMID: not available) (PDF) - Schoof M, Wang L, Cogan JZ, Lawrence R, Boone M, Wuerth JD, Frost A, Walter P. Viral Evasion of the Integrated Stress Response Through Antagonistic eIF2-P Mimicry. bioRxiv doi: https://doi.org/10.1101/2021.06.07.447473, 2021
(PMID: not available) (PDF) - Li W, Crotty K, Garrido Ruiz D, Voorhies M, Rivera C, Sil A, Mullins RD, Jacobson MP, Peschek J, Walter P. Protomer alignment modulates specificity of RNA substrate recognition by Ire1. eLife 10:e6742, 2021
(PMID: 33904404) (PDF) - Schoof M, Boone M, Wang L, Lawrence R, Frost A, Walter P. eIF2B conformation and assembly state regulate the integrated stress response. eLife 10:e65703, 2021
(PMID: 33688831) (PDF) - Li W, Crotty K, Ruiz DG, Voorhies M, Rivera C, Sil A, Mullins RD, Jacobson MP, Peschek J, Walter P. Protomer alignment modulates specificity of RNA substrate recognition by Ire1. bioRxiv doi: https://doi.org/10.1101/2021.02.10.430655, 2021
(PMID: not available) (PDF) - Vilarrasa-Blasi J, Fauser F, Onishi M, Ramundo S, Patena W, Millican M, Osaki J, Philp C, Nemeth M, Salomé PA, Li X, Wakao S, Kim RG, Kaye Y, Grossman AR, Niyogi KK, Merchant S, Cutler S, Walter P, Dinneny JR, Jonikas MC, Jinkerson RE. Systematic characterization of gene function in a photosynthetic organism. bioRxiv - preprint doi: https://doi.org/10.1101/2020.12.11.420950, 2020
(PMID: not available) (PDF) - Ramundo S, Asakura Y, Salomé PA, Strenkert D, Boone M, Mackinder LCM, Takafuji K, Dinc E, Rahire M, Crèvecoeur M, Magneschi L, Schaad O, Hippler M, Jonikas MC, Merchant S, Nakai M, Rochaix J-D, Walter P. Co-expressed subunits of dual genetic origin define a conserved supercomplex mediating essential protein import into chloroplasts. Proc Natl Acad Sci. 202014294, 2020
(PMID: 33273113) (PDF) - Krukowski K, Nolan A, Frias ES, Boone M, Ureta G, Grue K, Paladini M-S, Elizarraras E, Delgado L, Bernales S, Walter P, Rosi S. Small molecule cognitive enhancer reverses age-related memory decline in mice. eLife 9:e62048, 2020
(PMID: 33258451) (PDF) - Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 10.1126/science.abe3255, 2020
(PMID: 33154106) (PDF) - Wang L, Walter P. Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities. Annu. Rev. Cell Dev. 36:141–64, 2020
(PMID: 32886535) (PDF) - Rabouw HH, Visser LJ, Passchier TC, Langereis MA, Liu F, Giansanti P, van Vliet ALW, Dekker JG, van der Grein SG, Saucedo JG, Anand AA, Trellet ME, Bonvin AMJJ, Walter P, Heck AJR, de Groot RJ, van Kuppeveld FJM. Inhibition of the integrated stress response by viral proteins that block p-eIF2–eIF2B association. Nat Microbiol 5(11):1361-1373, 2020
(PMID: 32690955) (PDF) - Walter P, Mullins RD. To fight Covid-19, open access to scientific publishing. STAT, available online, 2020
(PMID: not available) - Krukowski K, Nolan A, Frias E, Grue K, Becker M, Ureta G, Delgado L, Bernales S, Sohal VS, Walter P, Rosi S. Integrated stress response inhibitor reverses sex-dependent behavioral and cell-specific deficits after mild repetitive head trauma. J Neurotrauma 37:1370–1380, 2020
(PMID: 31884883) (PDF) - Harnoss JM, Le Thomas A, Reichelt M, Guttman O, Wu TD, Marsters SA, Shemorry A, Lawrence DA, Kan D, Segal E, Merchant M, Totpal K, Crocker LM, Mesh K, Dohse M, Solon M, Modrusan Z, Rudolph J, Koeppen H, Walter P, Ashkenazi A. IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment. Cancer Res 80:2368-2379, 2020
(PMID: 32265225) (PDF) - Dufey E, Bravo-San Pedro JM, Eggers C, González-Quiroz M, Urra H, Sagredo AI, Sepulveda D, Pihán P, Carreras-Sureda A, Hazari Y, Sagredo EA, Gutierrez D, Valls C, Papaioannou A, Acosta-Alvear D, Campos G, Domingos PM, Pedeux R, Chevet E, Alvarez A, Godoy P, Walter P, Glavic A, Kroemer G, Hetz C. Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response. Nat Commun 11:2401, 2020
(PMID: 32409639) (PDF) - Costa-Mattioli M, Walter P. The integrated stress response: From mechanism to disease. Science 368:eaat5314. Review, 2020
(PMID: 32327570) (PDF) - Carter SD, Hampton CM, Langlois R, Melero R, Farino ZJ, Calderon MJ, Li W, Wallace CT, Tran NH, Grassucci RA, Siegmund SE, Pemberton J, Morgenstern TJ, Eisenman L, Aguilar JI, Greenberg NL, Levy ES, Yi E, Mitchell WG, Rice WJ, Wigge C, Pilli J, George EW, Aslanoglou D, Courel M, Freyberg RJ, Javitch JA, Wills ZP, Area-Gomez E, Shiva S, Bartolini F, Volchuk A, Murray SA, Aridor M, Fish KN, Walter P, Balla T, Fass D, Wolf SG, Watkins SC, Carazo JM, Jensen GJ, Frank J, Freyberg Z. Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells. Sci Adv 6:eaay9572, 2020
(PMID: 32270040) (PDF) - Göke A, Schrott S, Mizrak A, Belyy V, Osman C, Walter P. Mrx6 regulates mitochondrial DNA copy number in S. cerevisiae by engaging the evolutionarily conserved Lon protease Pim1. Mol Biol Cell. 31:527-545, 2020
(PMID: 31532710) (PDF) - Wang L, Myasnikov A, Pan X, Walter P. Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. eLife 9:e54031, 2020
(PMID: 31999255) (PDF) - Belyy V, Tran NH, Walter P. Quantitative microscopy reveals dynamics and fate of clustered IRE1α. Proc Natl Acad Sci 117:1533-1542, 2020
(PMID: 31871156) (PDF) - Lam M, Marsters S, Ashkenazi A, Walter P. Misfolded proteins bind and activate death receptor 5 to induce apoptosis during unresolved endoplasmic reticulum stress. eLife 9:e52291, 2020
(PMID: 1904339) (PDF) - Zhu PJ, Khatiwada S, Cui Y, Reineke LC, Dooling SW, Kim JJ, Li Wei, Walter P, Costa-Mattioli M. Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science 366:843-849, 2019
(PMID: 31727829) (PDF) - Perlaza K, Toutkoushian H, Boone M, Lam M, Iwai M, Jonikas MC, Walter P, Ramundo S. The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response. eLife 8:e49577, 2019
(PMID: 31612858) (PDF) - Anand AA, Walter P. Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response. FEBS J. Review. 10.1111/febs.15073, 2019
(PMID: 31550413) (PDF) - Walter P, Mullins D. From symbiont to parasite: the evolution of for-profit science publishing. Mol. Biol. Cell. 30:2537-2542, 2019
(PMID: 31539315) (PDF) - Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen Y-C A, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun M-G, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A. Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proc Natl Acad Sci 116:16420-16429, 2019
(PMID: 31371506) (PDF) - Peschek J, Walter P. tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. eLife 8:e44199, 2019
(PMID: 31237564) (PDF) - Torres SE, Gallagher CM, Plate L, Gupta M, Liem CR, Guo X, Tian R, Stroud RM, Kampmann M, Weissman JS, Walter P. Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. eLife 8:e46595, 2019
(PMID: 31149896) (PDF) - Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science 364:491-495, 2019
(PMID: 31048491) (PDF) - Rabouw HH, Langereis MA, Anand AA, Visser LJ, de Groot RJ, Walter P, van Kuppeveld FJM. The small molecule ISRIB suppresses the integrated stress response within a defined window of activation. Proc Natl Acad Sci 116:2097-2102, 2019
(PMID: 30674674) (PDF) - Karagöz GE, Acosta-Alvear D, Walter P. The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum. Cold Spring Harb Perspect Biol. Review 11:a033886, 2019
(PMID: 30670466) (PDF) - Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther T, Walter P. The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1. eLife 7:e43036, 2018
(PMID: 30582518) (PDF) - Lam M, Lawrence DA, Ashkenazi A, Walter P. Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress. Cell Death & Diff. 25:1530–1531, 2018
(PMID: 29991746) (PDF) - Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman J, Walter P. Engineering ER-stress dependent non-conventional mRNA splicing. eLife 7:e35388, 2018
(PMID: 29985129) (PDF) - Nguyen HG, Conn CS, Kye Y, Xue L, Forester CM, Cowan JE, Hsieh AC, Cunningham JT, Truillet C, Tameire F, Evans MJ, Evans CP, Yang JC, Hann B, Koumenis C, Walter P, Carroll PR, Ruggero D. Development of a stress response therapy targeting aggressive prostate cancer. Sci Transl Med 10:439, 2018
(PMID: 29720449) (PDF) - Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science 359:6383, 2018
(PMID: 29599213) (PDF) - Karagöz GE, Acosta-Alvear D, Nguyen HT, Lee CP, Chu F, Walter P. An unfolded protein-induced conformational switch activates mammalian IRE1. eLife 6:e30700, 2017
(PMID: 28971800) (PDF) - Guydosh NR, Kimmig P, Walter P, Green R. Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe. eLife 6:e29216, 2017
(PMID: 28945192) (PDF) - Cohen N, Breker M, Bakunts A, Pesek K, Chas A, Argemí J, Orsi A, Gal L, Chuartzmann S, Wigelman Y, Jonas F, Walter P, Ernst R, Aragón T, van Anken E, Schuldiner M. Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling. J of Cell Sci 130:3222-3233, 2017
(PMID: 28794014) (PDF) - Chou A, Krukowski K, Jopson T, Zhu PJ, Costa-Mattioli M, Walter P, Rosi S. Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Proc Natl Acad Sci E6420–E6426, 2017
(PMID: 28696288) (PDF) - Tufanli O, Telkoparan-Akillilar P, Acosta-Alvear D, Kocaturk B, Onata UI, Hamida SM, Cimen I, Walter P, Weber C, Erbay E. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci, 114:E1395-E1404, 2017
(PMID: 28137856) (PDF) - Rao M, Okreglak V, Chio US, Cho H, Walter P, Shan SO. Multiple selection filters ensure accurate tail-anchored membrane protein targeting. eLife 5:e21301, 2016
(PMID: 27925580) (PDF) - Placzek AN, Prisco GV, Khatiwada S, Sgritta M, Huang W, Krnjević K, Kaufman RJ, Dani JA, Walter P, Costa-Mattioli M. eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons. eLife e17517, 2016
(PMID: 27960077) (PDF) - Sabnis AJ, Guerriero CG, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton A, Paton J, Gestwicki J, Walter P, Weissman J, Wipf P, Brodsky J, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci 113:9015-20, 2016
(PMID: 27450084) (PDF) - Gallagher C, Garri C, Cain E, Ang K, Wilson C, Chen S, Hearn B, Jaishankar P, Aranda-Diaz A, Arkin M, Renslo A, Walter P. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. eLife 5:e11878, 2016
(PMID: 27435960) (PDF) - Gallagher C, Walter P. Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress. eLife 5:e11880, 2016
(PMID: 27435962) (PDF) - Plate L, Cooley C, Chen J, Paxman R, Gallagher C, Madoux F, Genereux J, Dobbs W, Garza D, Spicer T, Scampavia L, Brown S, Rosen H, Powers E, Walter P, Hodder P, Wiseman L, Kelly J. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. eLife 5:e15550, 2016
(PMID: 27435961) (PDF) - Huang W, Placzek AN, Di Prisco GV, Khatiwada S, Sidrauski C, Krnjević K, Walter P, Dani JA, Costa-Mattioli M. Translational control by eIF2α regulates adolescent vulnerability to the synaptic and 2 behavioral effects of cocaine. eLife 5:e12052, 2016
(PMID: 26928234) (PDF) - Placzek AN, Molfese DL, Khatiwada S, Di Prisco GV, Huang W, Sidrauski C, Krnjević K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M. Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α. eLife 5:e12056, 2016
(PMID: 26928076) (PDF) - Starck SR, Tsai JC, Chen K, Shodiya M, Wang L, Yahiro K, Martins-Green M, Shastri N, Walter P. Translation from the 5’ untranslated region shapes the integrated stress response. Science 351:6272, 2016
(PMID: 26823435) (PDF) - Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. Structure-activity studies of bis-O-arylglycolamides: inhibitors of the integrated stress response. Chem Med Chem 11:870-80, 2016
(PMID: 26789650) (PDF) - Elvekrog MM, Walter P. Dynamics of co-translational protein targeting. Chem Med Chem 29:79-86, Review, 2015
(PMID: 26517565) (PDF) - Peschek J, Acosta-Alvear D, Mendez AS, Walter P. A conformational RNA zipper promotes intron ejection during non‐conventional XBP1 mRNA splicing. EMBO Rep 16:1688–1698, 2015
(PMID: 26483401) (PDF) - Li X, Colvin T, Rauch JN, Acosta-Alvear D, Kampmann M, Dunyak B, Hann B, Aftab BT, Murnane M, Cho M, Walter P, Weissman JS, Sherman MY, Gestwicki JE. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther 14:642-8, 2015
(PMID: 25564440) (PDF) - Acosta-Alvear D, Cho M, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. eLife 4:e08153, 2015
(PMID: 26327686) (PDF) - Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez A, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. eLife 4:e07314, 2015
(PMID: 25875391) (PDF) - Sidrauski C, McGeachy A, Ingolia N, Walter P. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. eLife 4:e05033, 2015
(PMID: 25719440) (PDF) - Osman C, Noriega T, Okreglak V, Fung J, Walter P. Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion. Proc Nat Acad Sci 112:947-56, 2015
(PMID: 25730886) (PDF) - Lang AB, John Peter AT, Walter P, Kornmann B. ER-mitochondrial junctions can be bypassed by dominant mutations in the endosomal protein Vps13. J Cell Biol 210:883-90, 2015
(PMID: 26370498) (PDF) - Mendez A, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. eLife 4:e07314, 2015
(PMID: 25875391) (PDF) - Pincus D, Aranda-Díaz A, Zuleta IA, Walter P, El-Samad H. Delayed Ras/PKA signaling augments the unfolded protein response. Proc Natl Acad Sci 111:14800-5, 2014
(PMID: 25275008) (PDF) - Noriega T, Tsai A, Elvekrog M, Petrov A, Neher S, Chen J, Bradshaw N, Puglisi J, Walter P. Signal recognition particle-ribosome binding is sensitive to nascent chain length. J Biol Chem 289:19294-305, 2014
(PMID: 24808175) (PDF) - Okreglak V, Walter P. The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins. Proc Nat Acad Sci 111:8019–8024, 2014
(PMID: 24821790) (PDF) - Di Prisco G, Huang W, Buffington S, Hsu C, Bonnen P, Placzek A, Sidrauski C, Krnjević K, Kaufman R, Walter P, Costa-Mattioli M. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nat Neurosci 17:1073-82, 2014
(PMID: 24974795) (PDF) - Lu M, Lawrence D, Marsters S, Acosta-Alvear D, Kimmig P, Mendez A, Paton A, Paton J, Walter P, Ashkenazi A. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science 345:98-101, 2014
(PMID: 24994655) (PDF) - Schuck S, Gallagher C, Walter P. ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery. J Cell Sci 127:4078-4088, 2014
(PMID: 25052096) (PDF) - Noriega T, Chen J, Walter P, Puglisi J. Real-time observation of signal recognition particle binding to actively translating ribosomes. eLife 3:e04418, 2014
(PMID: 25358118) (PDF) - van Anken E, Pincus D, Coyle S, Aragón T, Osman C, Lari F, Puerta S, Korennykh A, Walter P. Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1. eLife 3:e05031, 2014
(PMID: 25549299) (PDF) - Lim B, Miyazaki R, Neher S, Siegele DA, Ito K, Walter P, Akiyama Y, Yura T, Gross CA. Heat shock transcription factor σ32 co-opts the signal recognition particle to regulate protein homeostasis in E. coli. PLoS Biol 11:e1001735, 2013
(PMID: 24358019) (PDF) - Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn B, Li H, Gamache K, Gallagher C, Ang K, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin M, Renslo A, Sonenberg N, Walter P. Pharmacological brake-release of mRNA translation enhances cognitive memory. eLife 2:e00498, 2013
(PMID: 23741617) (PDF) - Gardner B, Pincus D, Gotthardt K, Gallagher C, Walter P. Endoplasmic reticulum stress sensing in the unfolded protein response. Cold Spring Harb Perspect Biol 5:a013169, 2013
(PMID: 23388626) (PDF) - Murley A, Lackner L, Osman C, West M, Voeltz G, Walter P, Nunnari J. ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. eLife 2:e00422, 2013
(PMID: 23682313) (PDF) - Korennykh A, Walter P. Structural basis of the unfolded protein response. Annu Rev Cell Dev Biol 28:251-77, 2012
(PMID: 23057742) - Pincus D, Walter P. A first line of defense against ER stress. J Cell Biol 198:277-9, 2012
(PMID: 22869593) (PDF) - Moreira K, Schuck S, Schrul B, Fröhlich F, Moseley J, Walther T, Walter P. Seg1 controls eisosome assembly and shape. J Cell Biol 198:405-20, 2012
(PMID: 22869600) (PDF) - Fordyce P, Pincus D, Kimmig P, Nelson C, El-Samad H, Walter P, DeRisi J. Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses. Proc Nat Acad Sci 109:3084-93, 2012
(PMID: 23054834) (PDF) - Kimmig P, Diaz M, Zheng J, Williams C, Lang A, Aragón T, Li H, Walter P. The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis. eLife 1:e00048, 2012
(PMID: 23066505) (PDF) - Rubio C, Pincus D, Korennykh A, Schuck S, El-Samad H, Walter P. Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity. J Cell Biol 193:171-84, 2011
(PMID: 21444684) (PDF) - Korennykh A, Korostelev A, Egea P, Finer-Moore J, Stroud R, Zhang C, Shokat K, Walter P. Structural and functional basis for RNA cleavage by Ire1. BMC Biol 9:47, 2011
(PMID: 21729333) (PDF) - Korennykh A, Egea P, Korostelev A, Finer-Moore J, Stroud R, Zhang C, Shokat K, Walter P. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol 9:48, 2011
(PMID: 21729334) (PDF) - Nguyen T, Chandrasekar S, Neher S, Walter P, Shan S. Concerted complex assembly and GTPase activation in the chloroplast signal recognition particle. Biochemistry 50:7208-17, 2011
(PMID: 21780778) (PDF) - Kornmann B, Osman C, Walter P. The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections. Proc Natl Acad Sci 108:14151-6, 2011
(PMID: 21825164) (PDF) - Gardner B, Walter P. Unfolded proteins are Ire1-activating ligands that directly induce the unfolded protein response. Science 333:1891-4, 2011
(PMID: 21852455) (PDF) - Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court F, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C. BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response. EMBO J 30:4465-78, 2011
(PMID: 21926971) (PDF) - Braunstein MJ, Scott SS, Coplan JD, Scott CM, Behrman S, Walter P, Wipf P, Chrico WJ, Joseph D, Brodsky JL, Batuman O. Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101. J Oncol 2011:232037, 2011
(PMID: 21977030) (PDF) - Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 334:1081-6, 2011
(PMID: 22116877) (PDF) - Li H, Korennykh AV, Behrman SL, Walter P. Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. Proc Natl Acad Sci 107:16113–18, 2010
(PMID: 20798350) (PDF) - Pincus D, Chevalier MW, Aragón T, van Anken E, Vidal SE, El-Samad H, Walter P. BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response. PLoS Biol 8:e1000415, 2010
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(PMID: 2837764) (PDF) - Siegel V, Walter P. Functional dissection of the signal recognition particle. Trends Biochem Sci 13:314-6, 1988
(PMID: 2856455) (PDF) - Garcia P, Ou J, Rutter W, Walter P. Targeting of the hepatitis B virus precore protein to the endoplasmic reticulum membrane: after signal peptide cleavage translocation can be aborted and the product released into the cytoplasm. J Cell Biol 106:1093-104, 1988
(PMID: 3283145) (PDF) - Hansen W, Walter P. Prepro-carboxypeptidase Y and a truncated form of pre-invertase, but not full-length pre-invertase, can be posttranslationally translocated across microsomal vesicle membranes from Saccharomyces cerevisiae. J Cell Biol 106:1075-81, 1988
(PMID: 3283144) (PDF) - Siegel V, Walter P. Binding sites of the 19-kDa and 68/72-kDa signal recognition particle (SRP) proteins on SRP RNA as determined in protein-RNA “footprinting”. Proc Natl Acad Sci 85:1801-5, 1988
(PMID: 2450348) (PDF) - Garcia P, Walter P. Full-length prepro-alpha-factor can be translocated across the mammalian microsomal membrane only if translation has not terminated. J Cell Biol 106:1043-8, 1988
(PMID: 2834400) (PDF) - Siegel V, Walter P. The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length. EMBO J 7:1769-75, 1988
(PMID: 3169004) (PDF) - Lingelbach K, Zwieb C, Webb J, Marshallsay C, Hoben P, Walter P, Dobberstein B. Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA. Nucleic Acids Res 16:9431-42, 1988
(PMID: 2460823) (PDF) - Poritz MA, Strub K, Walter P. Human SRP RNA and E. coli 4.5S RNA contain a highly homologous structural domain. Cell 55:4-6, 1988
(PMID: 2458843) (PDF) - Wolin S, Walter P. Ribosome pausing and stacking during translation of a eukaryotic mRNA. EMBO J 7:3559-69, 1988
(PMID: 2850168) (PDF) - Siegel V, Walter P. Each of the activities of signal recognition particle (SRP) is contained within a distinct domain: analysis of biochemical mutants of SRP. Cell 52:39-49, 1988
(PMID: 2830980) (PDF) - Kassenbrock C, Garcia P, Walter P, Kelly R. Heavy-chain binding protein recognizes aberrant polypeptides translocated in vitro. Nature 333:90-3, 1988
(PMID: 3129663) (PDF) - Andrews D, Walter P, Ottensmeyer F. Evidence for an extended 7SL RNA structure in the signal recognition particle. EMBO J 6:3471-7, 1987
(PMID: 2828031) (PDF) - Garcia P, Ghrayeb J, Inouye M, Walter P. Wild type and mutant signal peptides of Escherichia coli outer membrane lipoprotein interact with equal efficiency with mammalian signal recognition particle. J Biol Chem 262:9463-8, 1987
(PMID: 3298258) (PDF) - Rapoport T, Heinrich R, Walter P, Schulmeister T. Mathematical Modeling of the Effects of the Signal Recognition Particle on Translation and Translocation of Proteins Across the Endoplasmic Reticulum Membrane. J Mol Biol 195:621-36, 1987
(PMID: 2821280) (PDF) - Walter P, Lingappa V. Mechanism of protein translocation across the endoplasmic reticulum membrane. Annu Rev Cell Biol 2:499-516, 1986
(PMID: 3030381) (PDF) - Krieg U, Walter P, Johnson A. Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle. Proc Natl Acad Sci 83:8604-8, 1986
(PMID: 3095839) (PDF) - Tajima S, Lauffer L, Rath V, Walter P. The signal recognition particle receptor is a complex that contains two distinct polypeptide chains. J Cell Biol 103:1167-7, 1986
(PMID: 3021779) (PDF) - Hansen W, Garcia P, Walter P. In vitro protein translocation across the yeast endoplasmic reticulum: ATP-dependent posttranslational translocation of the prepro-alpha-factor. Cell 45:397-406, 1986
(PMID: 3009026) (PDF) - Krieg UC, Walter P, Johnson AE. Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle. Proc Natl Acad Sci 83:8604-8, 1986
(PMID: 3095839) (PDF) - Andrews D, Walter P, Ottensmeyer F. Structure of the signal recognition particle by electron microscopy. Proc Natl Acad Sci 82:785-9, 1985
(PMID: 3856232) (PDF) - Bonatti S, Migliaccio G, Blobel G, Walter P. Role of signal recognition particle in the membrane assembly of Sindbis viral glycoproteins. Eur J Biochem 140:499-502, 1984
(PMID: 6723645) (PDF) - Walter P, Blobel G. Preparation of microsomal membranes for cotranslational protein translocation. Meth Enzymol 96:84-93, 1983
(PMID: 6656655) (PDF) - Blobel G. Signal recognition particle: a ribonucleoprotein required for cotranslational translocation of proteins, isolation and properties. Meth Enzymol 96:682-91, 1983
(PMID: 6197610) (PDF) - Walter P, Blobel G. Disassembly and reconstitution of signal recognition particle. Cell 34:525-33, 1983
(PMID: 6413076) (PDF) - Walter P, Blobel G. Subcellular distribution of signal recognition particle and 7SL-RNA determined with polypeptide-specific antibodies and complementary DNA probe. J Cell Biol 97:1693-9, 1983
(PMID: 6196367) (PDF) - Erickson A, Walter P, Blobel G. Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle. Biochem Biophys Res Commun 115:275-80, 1983
(PMID: 6137219) (PDF) - Walter P, Blobel G. Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum. Nature 299:691-8, 1982
(PMID: 6181418) (PDF) - Walter P, Blobel G. Mechanism of protein translocation across the endoplasmic reticulum. Biochem Soc Symp 47:183-91, 1982
(PMID: 6100822) - Anderson D, Walter P, Blobel G. Signal recognition protein is required for the integration of acetylcholine receptor delta subunit, a transmembrane glycoprotein, into the endoplasmic reticulum membrane. J Cell Biol 93:501-6, 1982
(PMID: 7047541) (PDF) - Müller M, Ibrahimi I, Chang C, Walter P, Blobel G. A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum. J Biol Chem 257:11860-3, 1982
(PMID: 6749848) (PDF) - Walter P, Gilmore R, Müller M, Blobel G. The protein translocation machinery of the endoplasmic reticulum. Philos Trans R Soc Lond B Biol Sci 300:225-8, 1982
(PMID: 6131460) (PDF) - Walter P, Ibrahimi I, Blobel G. Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol 91:545-50, 1981
(PMID: 7309795) (PDF) - Walter P, Blobel G. Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein. J Cell Biol 91:551-6, 1981
(PMID: 7309796) (PDF) - Walter P, Blobel G. Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes. J Cell Biol 91:557-61, 1981
(PMID: 7309797) (PDF) - Stoffel W, Blobel G, Walter P. Synthesis in vitro and translocation of apolipoprotein AI across microsomal vesicles. Eur J Biochem 120:519-22, 1981
(PMID: 6174327) (PDF) - Walter P, Blobel G. Purification of a membrane-associated protein complex required for protein translocation across the endoplasmic reticulum. Proc Natl Acad Sci U.S.A 77: 7112-6, 1980
(PMID: 6938958) (PDF) - Jackson R, Walter P, Blobel G. Secretion requires a cytoplasmically disposed sulphydryl of the RER membrane. Nature 286:174-6, 1980
(PMID: 6995850) (PDF) - Clevenstine E, Walter P, Harris T, Broquist H. Biosynthesis of slaframine, (1S,6S,8aS)-1-acetoxy-6-aminooctahydroindolizine, a parasympathomimetic alkaloid of fungal origin. 4. Metabolic fate of ethyl pipecolylacetate, 1,3-dioxooctahydroindolizine, and 1-hydroxyoctahydroindolizine in Rhizoctonia leguminicola. Biochemistry 18:3663-7, 1979
(PMID: 476078) (PDF) - Blobel G, Walter P, Chang C, Goldman B, Erickson A, Lingappa V. Translocation of proteins across membranes: the signal hypothesis and beyond. Symp Soc Exp Biol 33:9-36, 1979
(PMID: 524275) - Walter P, Jackson R, Marcus M, Lingappa V, Blobel G. Tryptic dissection and reconstitution of translocation activity for nascent presecretory proteins across microsomal membranes. Proc Natl Acad Sci 76:1795-9, 1979
(PMID: 109833) (PDF) - Walter P, Harris TM. Annelation of ethyl propiolate with ethyl pipecolate. J Org Chem 43:4250-4252, 1978
(PMID: not available) (PDF)