Morgane Boone

Morgane Boone

Alumni Postdoctoral Fellow

morgane@walterlab.ucsf.edu

Scientific Interest

The eukaryotic secretory system, protein folding stress, neurodegeneration, omics technologies 

Current Research Interests

Modulation of translation by the Integrated Stress Response in the brain

Former Lab Affiliations

2009 – 2010 Prof. Nico Callewaert – Master student, VIB/Ghent University
2010 – 2017 Prof. Nico Callewaert – Ph.D. student, VIB/Ghent University

Education

2005 – 2008  B. S. in Biochemistry & Biotechnology, Ghent University, Belgium
2008 – 2010 M.S. in Biochemistry & Biotechnology, Ghent University, Belgium
2010 – 2017 Ph.D. in Biochemistry & Biotechnology, Ghent University, Belgium

Selected Publications

Boone M, Wang L, Lawrence R, Frost A, Walter P, Schoof MA point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation. eLife 11:e76171, 2022
(PMID: 35416150

Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter PViral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Comms (2021) 12:7103, 2021
(PMID: not available) 

Schoof M, Wang L, Cogan JZ, Lawrence R, Boone M, Wuerth JD, Frost A, Walter PViral Evasion of the Integrated Stress Response Through Antagonistic eIF2-P Mimicry. bioRxiv doi: https://doi.org/10.1101/2021.06.07.447473, 2021
(PMID: not available) 

Schoof M, Boone M, Wang L, Lawrence R, Frost A, Walter PeIF2B conformation and assembly state regulate the integrated stress response. eLife 10:e65703, 2021
(PMID: 33688831

Ramundo S, Asakura Y, Salomé PA, Strenkert D, Boone M, Mackinder LCM, Takafuji K, Dinc E, Rahire M, Crèvecoeur M, Magneschi L, Schaad O, Hippler M, Jonikas MC, Merchant S, Nakai M, Rochaix J-D, Walter PCo-expressed subunits of dual genetic origin define a conserved supercomplex mediating essential protein import into chloroplasts. Proc Natl Acad Sci. 202014294, 2020
(PMID: 33273113

Krukowski K, Nolan A, Frias ES, Boone M, Ureta G, Grue K, Paladini M-S, Elizarraras E, Delgado L, Bernales S, Walter P, Rosi S. Small molecule cognitive enhancer reverses age-related memory decline in mice. eLife 9:e62048, 2020
(PMID: 33258451

Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 10.1126/science.abe3255, 2020
(PMID: 33154106

Perlaza K, Toutkoushian H, Boone M, Lam M, Iwai M, Jonikas MC, Walter P, Ramundo SThe Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response. eLife 8:e49577, 2019
(PMID: 31612858