Lan Wang

Alumni Postdoctoral Fellow

Scientific Interest

Mechanism of protein trafficking and folding, structural basis of signaling pathways, protein-DNA interactions

Current Research Interests

Mechanism of activation of the ER stress sensors

Former Lab Affiliations

2008-2009	Dr. Chan-Juan xi, Tsinghua University, China
2009-2011	Dr. Yan-Mei Li, Tsinghua University, China
2010	Dr. Erin Carlson, Indiana University Bloomington
2012-2015	Dr. Gregory Verdine, Harvard University

Education

2007-2011	BS Chemistry – Tsinghua University, China
2011-2016	Ph.D Harvard University

Selected Publications

Boone M, Wang L, Lawrence R, Frost A, Walter P, Schoof M. A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation. eLife 11:e76171, 2022 Publication identifiers: (PMID: 35416150)
Le Thomas A, Ferri E, Marsters S, Harnoss JM, Lawrence DA, Zuazo-Gaztelu I, Modrusan Z, Chan S, Solon M, Chalouni C, Li W, Koeppen H, Rudolph J, Wang W, Wu TD, Walter P, Ashkenazi A. Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α. Nat Comms DOI: 10.1038/s41467-021-27597-7, 2021 Publication identifiers: (PMID: not available)
Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter P. Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Comms (2021) 12:7103, 2021 Publication identifiers: (PMID: not available)
Wang L, Toutkoushian H, Belyy V, Kokontis C, Walter P. Conserved structural elements specialize ATAD1 as a membrane protein extraction machine. bioRxiv DOI: 10.1101/2021.09.24.461712, 2021 Publication identifiers: (PMID: not available)
Schoof M, Wang L, Cogan JZ, Lawrence R, Boone M, Wuerth JD, Frost A, Walter P. Viral Evasion of the Integrated Stress Response Through Antagonistic eIF2-P Mimicry. bioRxiv doi: https://doi.org/10.1101/2021.06.07.447473, 2021 Publication identifiers: (PMID: not available)
Schoof M, Boone M, Wang L, Lawrence R, Frost A, Walter P. eIF2B conformation and assembly state regulate the integrated stress response. eLife 10:e65703, 2021 Publication identifiers: (PMID: 33688831)
Wang L, Walter P. Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities. Annu. Rev. Cell Dev. 36:141–64, 2020 Publication identifiers: (PMID: 32886535)
Wang L, Myasnikov A, Pan X, Walter P. Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. eLife 9:e54031, 2020 Publication identifiers: (PMID: 31999255)
Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen Y-C A, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun M-G, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A. Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proc Natl Acad Sci 116:16420-16429, 2019 Publication identifiers: (PMID: 31371506)
Starck SR, Tsai JC, Chen K, Shodiya M, Wang L, Yahiro K, Martins-Green M, Shastri N, Walter P. Translation from the 5’ untranslated region shapes the integrated stress response. Science 351:6272, 2016 Publication identifiers: (PMID: 26823435)