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The unfolded protein response: an intracellular signalling pathway with many surprising features.

Sidrauski C, Chapman R, Walter P. The unfolded protein response: an intracellular signalling pathway with many surprising features. Trends Cell Biol 8:245-9, 1998
(PMID : 9695849) (PDF)

Abstract

The unfolded protein response (UPR) is an intracellular signalling pathway–originating in the endoplasmic reticulum (ER) and leading to the cell nucleus–that controls transcription of genes encoding ER-resident proteins. Recent developments in this field show that this pathway utilizes unique regulatory mechanisms, including translational attenuation and a regulated mRNA splicing step catalysed by a bifunctional transmembrane kinase/endoribonuclease and tRNA ligase. This review describes the characterization of the UPR signalling pathway, focusing on the novel regulatory mechanisms that it has revealed.


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