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Functional dissection of the signal recognition particle.

Siegel V, Walter P. Functional dissection of the signal recognition particle. Trends Biochem Sci 13:314-6, 1988
(PMID : 2856455) (PDF)

Abstract

Biochemical mutagenesis – alteration or removal of specific domains within a biological structure -followed by functional analysis, gives insight into structure-function relationships. We describe the analysis of the signal recognition particle, a ribonucleoprotein known to be required for the entry of most proteins into the secretory pathway, as an example of the strength of this approach.


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