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Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle.

Erickson A, Walter P, Blobel G. Translocation of a lysosomal enzyme across the microsomal membrane requires signal recognition particle. Biochem Biophys Res Commun 115:275-80, 1983
(PMID : 6137219) (PDF)

Abstract

Signal recognition particle (SRP), an 11S ribonucleoprotein (Walter and Blobel (1982) Nature 299, 691-698), is required for translocation of secretory proteins across microsomal membranes (Walter and Blobel (1980) Proc. Natl. Acad. Sci. USA 77, 7112-7116) and for asymmetric integration into microsomal membranes of a transmembrane protein (Anderson et al., (1982) J. Cell Biol. 93, 501-506). We demonstrate here that SRP is also required for translocation of the lysosomal protease cathepsin D across microsomal membranes


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