Tobias Walther

Alumni Postdoc

Science by a power of two

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September 22, 2015 — When Robert Farese and Tobias Walther were negotiating to join Harvard T.H. Chan School of Public Health last year as professors of genetics and complex diseases, they proposed a twist to their appointments—a joint laboratory run as an equal partnership. Although they were working in different institutions and came from different disciplines—Farese from physiology and biomedicine, Walther from cell biology and biochemistry —they had been collaborating remotely for a decade, finding fertile ground in their shared research interests, scientific values, and wide-ranging curiosity. Read more…

http://www.hsph.harvard.edu/news/features/science-by-a-power-of-two/?utm_source=Facebook&utm_medium=Social&utm_campaign=Chan-Facebook-General

Selected Publications

Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther T, Walter P. The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1. eLife 7:e43036, 2018
(PMID: 30582518)

Moreira K, Schuck S, Schrul B, Fröhlich F, Moseley J, Walther T, Walter P. Seg1 controls eisosome assembly and shape. J Cell Biol 198:405-20, 2012
(PMID: 22869600)

Aguilar PS, Fröhlich F, Rehman M, Shales M, Ulitsky I, Olivera-Couto A, Braberg H, Shamir R, Walter P, Mann M, Ejsing CS, Krogan NJ, Walther TC. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Nat Struct Mol Biol 7:901-8, 2010
(PMID: 20526336)

Aguilar PS, Heiman MG, Walther TC, Engel A, Schwudke D, Gushwa N, Kurzchalia T, Walter P. Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating. PNAS 9:4170-5, 2010
(PMID: 20150508)

Moreira K, Walther T, Aguilar P, Walter P. Pil1 Controls Eisosome Biogenesis. Mol Biol Cell 20:809-18, 2009
(PMID: 19037108)

Fröhlich F, Moreira K, Aguilar P, Hubner N, Mann M, Walter P, Walther T. A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling. J Cell Biol 185:1227-42, 2009
(PMID: 19564405)

Guo Y, Walther T, Rao M, Stuurman N, Goshima G, Terayama K, Wong J, Vale R, Walter P, Farese R. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature 453:657-61, 2008
(PMID: 18408709)

Walther T, Aguilar P, Fröhlich F, Chu F, Moreira K, Burlingame A, Walter P. Pkh-kinases control eisosome assembly and organization. EMBO J 26:4946-55, 2007
(PMID: 18034155)

Walther TC, Brickner JH, Aguilar PS, Bernales S, Pantoja C, Walter P. Eisosomes mark static sites of endocytosis. Nature 439:998-1003, 2006
(PMID: 16496001)