Michael Schoof

Michael Schoof

Alumni Graduate Student

michael@walterlab.ucsf.edu

Scientific Interest

Molecular mechanisms of aging; Pharmacological modulation of aging and aging-associated phenotypes

Current Research Interests

Understanding how regulation of the integrated stress response impacts memory

Former Lab Affiliations

2011-2012Dr. Carrie Rinker-Schaeffer, University of Chicago, Chicago IL
2012-2016Dr. Anne Brunet, Stanford University, Stanford CA
2013Dr. Richard Morimoto, Northwestern University, Evanston IL
2016-2017Dr. Julie Ahringer, University of Cambridge Gurdon Institute, Cambridge UK

 

Education

2012-2016B.S. Molecular, Cellular, and Developmental Biology – Stanford University, Stanford CA
2016-2017MPhil Genetics – University of Cambridge, Churchill College, Cambridge UK

 

Selected Publications

Boone M, Wang L, Lawrence R, Frost A, Walter P, Schoof MA point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation. eLife 11:e76171, 2022
(PMID: 35416150) (PDF)

Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter PViral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Comms (2021) 12:7103, 2021
(PMID: not available) (PDF)

Schoof M, Wang L, Cogan JZ, Lawrence R, Boone M, Wuerth JD, Frost A, Walter PViral Evasion of the Integrated Stress Response Through Antagonistic eIF2-P Mimicry. bioRxiv doi: https://doi.org/10.1101/2021.06.07.447473, 2021
(PMID: not available) (PDF)

Schoof M, Boone M, Wang L, Lawrence R, Frost A, Walter PeIF2B conformation and assembly state regulate the integrated stress response. eLife 10:e65703, 2021
(PMID: 33688831) (PDF)

Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 10.1126/science.abe3255, 2020
(PMID: 33154106) (PDF)