Boone M, Wang L, Lawrence R, Frost A, Walter P, Schoof M. A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation. eLife 11:e76171, 2022
(PMID: 35416150) (PDF)
Le Thomas A, Ferri E, Marsters S, Harnoss JM, Lawrence DA, Zuazo-Gaztelu I, Modrusan Z, Chan S, Solon M, Chalouni C, Li W, Koeppen H, Rudolph J, Wang W, Wu TD, Walter P, Ashkenazi A. Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α. Nat Comms DOI: 10.1038/s41467-021-27597-7, 2021
(PMID: not available) (PDF)
Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter P. Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Comms (2021) 12:7103, 2021
(PMID: not available) (PDF)
Wang L, Toutkoushian H, Belyy V, Kokontis C, Walter P. Conserved structural elements specialize ATAD1 as a membrane protein extraction machine. bioRxiv DOI: 10.1101/2021.09.24.461712, 2021
(PMID: not available) (PDF)
Schoof M, Wang L, Cogan JZ, Lawrence R, Boone M, Wuerth JD, Frost A, Walter P. Viral Evasion of the Integrated Stress Response Through Antagonistic eIF2-P Mimicry. bioRxiv doi: https://doi.org/10.1101/2021.06.07.447473, 2021
(PMID: not available) (PDF)
Schoof M, Boone M, Wang L, Lawrence R, Frost A, Walter P. eIF2B conformation and assembly state regulate the integrated stress response. eLife 10:e65703, 2021
(PMID: 33688831) (PDF)
Wang L, Walter P. Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities. Annu. Rev. Cell Dev. 36:141–64, 2020
(PMID: 32886535) (PDF)
Wang L, Myasnikov A, Pan X, Walter P. Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. eLife 9:e54031, 2020
(PMID: 31999255) (PDF)
Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen Y-C A, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun M-G, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A. Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proc Natl Acad Sci 116:16420-16429, 2019
(PMID: 31371506) (PDF)
Starck SR, Tsai JC, Chen K, Shodiya M, Wang L, Yahiro K, Martins-Green M, Shastri N, Walter P. Translation from the 5’ untranslated region shapes the integrated stress response. Science 351:6272, 2016
(PMID: 26823435) (PDF)
