Huang W, Placzek AN, Di Prisco GV, Khatiwada S, Sidrauski C, Krnjević K, Walter P, Dani JA, Costa-Mattioli M. Translational control by eIF2α regulates adolescent vulnerability to the synaptic and 2 behavioral effects of cocaine. eLife 5:e12052, 2016
(PMID: 26928234) (PDF)
Placzek AN, Molfese DL, Khatiwada S, Di Prisco GV, Huang W, Sidrauski C, Krnjević K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M. Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α. eLife 5:e12056, 2016
(PMID: 26928076) (PDF)
Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. Structure-activity studies of bis-O-arylglycolamides: inhibitors of the integrated stress response. Chem Med Chem 11:870-80, 2016
(PMID: 26789650) (PDF)
Sidrauski C, McGeachy A, Ingolia N, Walter P. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. eLife 4:e05033, 2015
(PMID: 25719440) (PDF)
Mendez A, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. eLife 4:e07314, 2015
(PMID: 25875391) (PDF)
Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez A, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. eLife 4:e07314, 2015
(PMID: 25875391) (PDF)
Di Prisco G, Huang W, Buffington S, Hsu C, Bonnen P, Placzek A, Sidrauski C, Krnjević K, Kaufman R, Walter P, Costa-Mattioli M. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nat Neurosci 17:1073-82, 2014
(PMID: 24974795) (PDF)
Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn B, Li H, Gamache K, Gallagher C, Ang K, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin M, Renslo A, Sonenberg N, Walter P. Pharmacological brake-release of mRNA translation enhances cognitive memory. eLife 2:e00498, 2013
(PMID: 23741617) (PDF)
Nock S, Gonzalez TN, Sidrauski C, Niwa M, Walter P. Purification and activity assays of the catalytic domains of the kinase/endoribonuclease Ire1p from Saccharomyces cerevisiae. Meth Enzymol 342:3-10, 2001
(PMID: 11586903) (PDF)
Gonzalez TN, Sidrauski C, Nock S, Walter P. Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J. 11:3119-32, 1999
(PMID: 10357823) (PDF)
Niwa M, Sidrauski C, Kaufman R, Walter P. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99:691-702, 1999
(PMID: 10619423) (PDF)
Sidrauski C, Chapman R, Walter P. The unfolded protein response: an intracellular signalling pathway with many surprising features. Trends Cell Biol 8:245-9, 1998
(PMID: 9695849) (PDF)
Sidrauski C, Walter P. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90:1031-9, 1997
(PMID: 9323131) (PDF)
Sidrauski C, Cox J, Walter P. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87:405-13, 1996
(PMID: 8898194) (PDF)