Walter Lab

  • Walter Lab
  • Research
  • Lab Members
    • Current
    • Alumni
  • Contact Us
  • Social
  • Publications
  • News & Notes

Aditya Anand

Aditya Anand

Alumni Graduate Student

Aditya@walterlab.ucsf.edu

AdityaAnand_CV

Scientific Interest:

Proteins execute a vast array of cellular functions from cell signaling to ion transport to structural support.  To carry out these tasks, proteins adopt unique shapes in a process called protein folding. When proteins lose their shape, or “unfold”, they fail to function correctly and can further cause other proteins to unfold. A signaling network known as the integrated stress response (ISR) protects cells under these conditions by triggering a shut down of global protein synthesis. This pause in the production of proteins allows cells time and resources to mitigate protein unfolding-induced stress and prevent plaque-like aggregation. While great strides have been made in characterizing the ISR, there is more to be learned about stress responses and translational control. I am interested in furthering our mechanistic knowledge of the ISR and parallel pathways that regulate the synthesis of new proteins.

Current research interest:

Recently a small molecule modulator of the ISR called ISRIB (integrated stress response inhibitor) was discovered in our lab. My work is focused on determining a mechanism of action for this compound that can explain its blunting effects on the ISR.

Former Lab Affiliations

2010-2013 Dr. John Tainer , Lawrence Berkeley National Laboratory

Education

2007-2011 BA Molecular and Cell Biology, University of California, Berkeley
2011-Present PhD Biochemistry, University of California, San Francisco

Selected Publications

Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium, Walter P, Manglik A. An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science. 10.1126/science.abe3255, 2020
(PMID : 33154106) (PDF)
Anand AA, Walter P. Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response. FEBS J. Review. 10.1111/febs.15073, 2019
(PMID : 31550413) (PDF)
Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science 364:491-495, 2019
(PMID : 31048491) (PDF)
Rabouw HH, Langereis MA, Anand AA, Visser LJ, de Groot RJ, Walter P, van Kuppeveld FJM. The small molecule ISRIB suppresses the integrated stress response within a defined window of activation. Proc Natl Acad Sci 116:2097-2102, 2019
(PMID : 30674674) (PDF)
Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science 359:6383, 2018
(PMCID : PMC6120582) (PMID : 29599213) (PDF)

© 2025 Walter Lab | University of California, San Francisco | Howard Hughes Medical Institute