Christof Osman

Alumni Postdoctoral Fellow

Current Position

Group Leader
Department Biology II
Biocenter of the LMU
Großhaderner Str. 2
82152 Planegg-Martinsried
Germany
Phone: +49 (0)89 2180 74756
osman@bio.lmu.de

Scientific Interest

I am fascinated by the molecular mechanisms that determine cellular organization and adjust it in response to changing demands.

Current Research Interests

Mechanisms of mtDNA distribution within the mitochondrial network of S. cerevisiae

Former Lab Affiliations

2005-2010

Prof. Dr. Thomas Langer – Graduate Student, University of Cologne

Education

1999-2002	Undergraduate Studies Biology – Rheinische-Friedrich-Wilhelms-Universität Bonn, Germany
2002-2005	Diploma Biology – University of Cologne, Germany

Selected Publications

Göke A, Schrott S, Mizrak A, Belyy V, Osman C, Walter P. Mrx6 regulates mitochondrial DNA copy number in S. cerevisiae by engaging the evolutionarily conserved Lon protease Pim1. Mol Biol Cell. 31:527-545, 2020
(PMID: 31532710) (PDF)

Osman C, Noriega T, Okreglak V, Fung J, Walter P. Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion. Proc Nat Acad Sci 112:947-56, 2015
(PMID: 25730886) (PDF)

van Anken E, Pincus D, Coyle S, Aragón T, Osman C, Lari F, Puerta S, Korennykh A, Walter P. Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1. eLife 3:e05031, 2014
(PMID: 25549299) (PDF)

Murley A, Lackner L, Osman C, West M, Voeltz G, Walter P, Nunnari J. ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. eLife 2:e00422, 2013
(PMID: 23682313) (PDF)

Kornmann B, Osman C, Walter P. The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections. Proc Natl Acad Sci 108:14151-6, 2011
(PMID: 21825164) (PDF)