Shu-ou Shan
Alumni Postdoc
Selected Publications
- Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science 359:6383, 2018
- Rao M, Okreglak V, Chio US, Cho H, Walter P, Shan SO. Multiple selection filters ensure accurate tail-anchored membrane protein targeting. eLife 5:e21301, 2016
- Gallagher C, Garri C, Cain E, Ang K, Wilson C, Chen S, Hearn B, Jaishankar P, Aranda-Diaz A, Arkin M, Renslo A, Walter P. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. eLife 5:e11878, 2016
- Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. Structure-activity studies of bis-O-arylglycolamides: inhibitors of the integrated stress response. Chem Med Chem 11:870-80, 2016
- Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez A, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. eLife 4:e07314, 2015
- Nguyen T, Chandrasekar S, Neher S, Walter P, Shan S. Concerted complex assembly and GTPase activation in the chloroplast signal recognition particle. Biochemistry 50:7208-17, 2011
- Shan S, Chandrasekar S, Walter P. Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation. J Cell Biol 178:611-20, 2007
- Shan S, Walter P. Co-translational protein targeting by the signal recognition particle. FEBS Lett 579: 921-6, 2005
- Chu F, Shan S, Moustakas D, Alber F, Egea P, Stroud R, Walter P, Burlingame A. Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry. Proc Natl Acad Sci 101:16454-9, 2004
- Shan S, Stroud R, Walter P. Mechanism of association and reciprocal activation of two GTPases. PLoS Biol 2:e320, 2004
- Egea P, Shan S, Napetschnig J, Savage D, Walter P, Stroud R. Substrate twinning activates the signal recognition particle and its receptor. Nature 427:215-21, 2004
- Shan S, Walter P. Induced nucleotide specificity in a GTPase. Proc Natl Acad Sci 100:4480-5, 2003
- Peluso P, Shan S, Nock S, Herschlag D, Walter P. Role of SRP RNA in the GTPase cycles of Ffh and FtsY. Biochemistry 40:15224-33, 2001