Carmela Sidrauski

Selected Publications

• Huang W, Placzek AN, Di Prisco GV, Khatiwada S, Sidrauski C, Krnjević K, Walter P, Dani JA, Costa-Mattioli M. Translational control by eIF2α regulates adolescent vulnerability to the synaptic and 2 behavioral effects of cocaine. eLife 5:e12052, 2016 Publication identifiers: (PMID: 26928234)
• Placzek AN, Molfese DL, Khatiwada S, Di Prisco GV, Huang W, Sidrauski C, Krnjević K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M. Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α. eLife 5:e12056, 2016 Publication identifiers: (PMID: 26928076)
• Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. Structure-activity studies of bis-O-arylglycolamides: inhibitors of the integrated stress response. Chem Med Chem 11:870-80, 2016 Publication identifiers: (PMID: 26789650)
• Sidrauski C, McGeachy A, Ingolia N, Walter P. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. eLife 4:e05033, 2015 Publication identifiers: (PMID: 25719440)
• Mendez A, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. eLife 4:e07314, 2015 Publication identifiers: (PMID: 25875391)
• Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez A, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. eLife 4:e07314, 2015 Publication identifiers: (PMID: 25875391)
• Di Prisco G, Huang W, Buffington S, Hsu C, Bonnen P, Placzek A, Sidrauski C, Krnjević K, Kaufman R, Walter P, Costa-Mattioli M. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nat Neurosci 17:1073-82, 2014 Publication identifiers: (PMID: 24974795)
• Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn B, Li H, Gamache K, Gallagher C, Ang K, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin M, Renslo A, Sonenberg N, Walter P. Pharmacological brake-release of mRNA translation enhances cognitive memory. eLife 2:e00498, 2013 Publication identifiers: (PMID: 23741617)
• Nock S, Gonzalez TN, Sidrauski C, Niwa M, Walter P. Purification and activity assays of the catalytic domains of the kinase/endoribonuclease Ire1p from Saccharomyces cerevisiae. Meth Enzymol 342:3-10, 2001 Publication identifiers: (PMID: 11586903)
• Gonzalez TN, Sidrauski C, Nock S, Walter P. Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathway. EMBO J. 11:3119-32, 1999 Publication identifiers: (PMID: 10357823)
• Niwa M, Sidrauski C, Kaufman R, Walter P. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99:691-702, 1999 Publication identifiers: (PMID: 10619423)
• Sidrauski C, Chapman R, Walter P. The unfolded protein response: an intracellular signalling pathway with many surprising features. Trends Cell Biol 8:245-9, 1998 Publication identifiers: (PMID: 9695849)
• Sidrauski C, Walter P. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90:1031-9, 1997 Publication identifiers: (PMID: 9323131)
• Sidrauski C, Cox J, Walter P. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87:405-13, 1996 Publication identifiers: (PMID: 8898194)