Carmela Sidrauski

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Alumni Graduate Student/Research Specialist

carmela@walterlab.ucsf.edu

Scientific Interest

I am interested in stress signaling pathways (the proteins involved, how they function and how they are regulated) and their dysregulation in disease

Current Research Interests

The Integrated Stress Response pathway in neurodegeneration and cognition

Former Lab Affiliations

1990-1992	Dr. Israel Algranati – Undergraduate Research Fellow, Institute Francisco Leloir, Buenos Aires, Argentina
1992-1994	Tyler Jacks – Graduate Student, Cancer Center, Massachusetts Institute of Technology
1994-1998	Dr. Peter Walter – Graduate Student, Department of Biochemistry and Biophysics, University of California at San Francisco
1998-2000	Dr. Peter Walter – Post-Doctoral Research Fellow, University of California, San Francisco

Education

1992	M.S. Biology – University of Buenos Aires, Argentina,
1999	Ph.D Cell Biology – University of California, San Francisco, USA

Links

Selected Publications

Huang W, Placzek AN, Di Prisco GV, Khatiwada S, Sidrauski C, Krnjević K, Walter P, Dani JA, Costa-Mattioli M. Translational control by eIF2α regulates adolescent vulnerability to the synaptic and 2 behavioral effects of cocaine. eLife 5:e12052, 2016
(PMCID : 4786430) (PMID : 26928234) (PDF)

Placzek AN, Molfese DL, Khatiwada S, Di Prisco GV, Huang W, Sidrauski C, Krnjević K, Amos CL, Ray R, Dani JA, Walter P, Salas R, Costa-Mattioli M. Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α. eLife 5:e12056, 2016
(PMCID : 4786418) (PMID : 26928076) (PDF)

Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. Structure-activity studies of bis-O-arylglycolamides: inhibitors of the integrated stress response. Chem Med Chem 11:870-80, 2016
(PMID : 26789650) (PDF)

Sidrauski C, McGeachy A, Ingolia N, Walter P. The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly. eLife 4:e05033, 2015
(PMCID : PMC4341466) (PMID : 25719440) (PDF)

Mendez A, Alfaro J, Morales-Soto MA, Dar AC, McCullagh E, Gotthardt K, Li H, Acosta-Alvear D, Sidrauski C, Korennykh AV, Bernales S, Shokat KM, Walter P. Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. eLife 4:e07314, 2015
(PMCID : PMC4436593) (PMID : 25875391) (PDF)

Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez A, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. eLife 4:e07314, 2015
(PMCID : PMC4426669) (PMID : 25875391) (PDF)

Di Prisco G, Huang W, Buffington S, Hsu C, Bonnen P, Placzek A, Sidrauski C, Krnjević K, Kaufman R, Walter P, Costa-Mattioli M. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nat Neurosci 17:1073-82, 2014
(PMCID : PMC4340591) (PMID : 24974795) (PDF)

Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn B, Li H, Gamache K, Gallagher C, Ang K, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin M, Renslo A, Sonenberg N, Walter P. Pharmacological brake-release of mRNA translation enhances cognitive memory. eLife 2:e00498, 2013
(PMCID : PMC3667625) (PMID : 23741617) (PDF)

Niwa M, Sidrauski C, Kaufman R, Walter P. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99:691-702, 1999
(PMID : 10619423) (PDF)

Sidrauski C, Chapman R, Walter P. The unfolded protein response: an intracellular signalling pathway with many surprising features. Trends Cell Biol 8:245-9, 1998
(PMID : 9695849) (PDF)

Sidrauski C, Walter P. The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90:1031-9, 1997
(PMID : 9323131) (PDF)

Sidrauski C, Cox J, Walter P. tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Cell 87:405-13, 1996
(PMID : 8898194) (PDF)