Jirka Peschek

Alumni Postdoctoral Fellow

jirka@walterlab.ucsf.edu

Scientific Interest

Biomolecular interactions and mechanisms involved in protein folding and cellular homeostasis

Current Research Interests

Structure-function relationship of the ER stress sensor Ire1, organization of unconventional splicing during Ire1-mediated signaling

Former Lab Affiliations

2007	Prof. Johannes Buchner – Master Student, Technische Universität München
2008-2012	Prof. Johannes Buchner – Ph.D Student, Technische Universität München

Education

2002-2005	B.S. Biochemistry – Technische Universität München, Germany
2005-2007	MS Biochemistry – Technische Universität München, Germany
2008-2012	Ph.D Biochemistry – Technische Universität München,

Selected Publications

Peschek J, Walter P. tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. eLife 8:e44199, 2019
(PMCID : PMC6592678) (PMID : 31237564) (PDF)

Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman J, Walter P. Engineering ER-stress dependent non-conventional mRNA splicing. eLife 7:e35388, 2018
(PMID : 29985129) (PDF)

Peschek J, Acosta-Alvear D, Mendez AS, Walter P. A conformational RNA zipper promotes intron ejection during non‐conventional XBP1 mRNA splicing. EMBO Rep 16:1688–1698, 2015
(PMCID : 4687415) (PMID : 26483401) (PDF)