Scientific Interest
Biomolecular interactions and mechanisms involved in protein folding and cellular homeostasis
Current Research Interests
Structure-function relationship of the ER stress sensor Ire1, organization of unconventional splicing during Ire1-mediated signaling
Former Lab Affiliations
| 2007 |
Prof. Johannes Buchner – Master Student, Technische Universität München |
| 2008-2012 |
Prof. Johannes Buchner – Ph.D Student, Technische Universität München |
Education
| 2002-2005 |
B.S. Biochemistry – Technische Universität München, Germany |
| 2005-2007 |
MS Biochemistry – Technische Universität München, Germany |
| 2008-2012 |
Ph.D Biochemistry – Technische Universität München, |
Selected Publications
Li W, Crotty K, Garrido Ruiz D, Voorhies M, Rivera C, Sil A, Mullins RD, Jacobson MP, Peschek J, Walter P. Protomer alignment modulates specificity of RNA substrate recognition by Ire1. eLife 10:e6742, 2021
(PMID: 33904404) (PDF)
Li W, Crotty K, Ruiz DG, Voorhies M, Rivera C, Sil A, Mullins RD, Jacobson MP, Peschek J, Walter P. Protomer alignment modulates specificity of RNA substrate recognition by Ire1. bioRxiv doi: https://doi.org/10.1101/2021.02.10.430655, 2021
(PMID: not available) (PDF)
Peschek J, Walter P. tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. eLife 8:e44199, 2019
(PMID: 31237564) (PDF)
Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman J, Walter P. Engineering ER-stress dependent non-conventional mRNA splicing. eLife 7:e35388, 2018
(PMID: 29985129) (PDF)
Peschek J, Acosta-Alvear D, Mendez AS, Walter P. A conformational RNA zipper promotes intron ejection during non‐conventional XBP1 mRNA splicing. EMBO Rep 16:1688–1698, 2015
(PMID: 26483401) (PDF)
