Jirka Peschek

Alumni Postdoctoral Fellow

jirka@localhost

Scientific Interest

Biomolecular interactions and mechanisms involved in protein folding and cellular homeostasis

Current Research Interests

Structure-function relationship of the ER stress sensor Ire1, organization of unconventional splicing during Ire1-mediated signaling

Former Lab Affiliations

2007	Prof. Johannes Buchner – Master Student, Technische Universität München
2008-2012	Prof. Johannes Buchner – Ph.D Student, Technische Universität München

Education

2002-2005	B.S. Biochemistry – Technische Universität München, Germany
2005-2007	MS Biochemistry – Technische Universität München, Germany
2008-2012	Ph.D Biochemistry – Technische Universität München,

Selected Publications

Li W, Crotty K, Garrido Ruiz D, Voorhies M, Rivera C, Sil A, Mullins RD, Jacobson MP, Peschek J, Walter P. Protomer alignment modulates specificity of RNA substrate recognition by Ire1. eLife 10:e6742, 2021 Publication identifiers: (PMID: 33904404)
Li W, Crotty K, Ruiz DG, Voorhies M, Rivera C, Sil A, Mullins RD, Jacobson MP, Peschek J, Walter P. Protomer alignment modulates specificity of RNA substrate recognition by Ire1. bioRxiv doi: https://doi.org/10.1101/2021.02.10.430655, 2021 Publication identifiers: (PMID: not available)
Peschek J, Walter P. tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. eLife 8:e44199, 2019 Publication identifiers: (PMID: 31237564)
Li W, Okreglak V, Peschek J, Kimmig P, Zubradt M, Weissman J, Walter P. Engineering ER-stress dependent non-conventional mRNA splicing. eLife 7:e35388, 2018 Publication identifiers: (PMID: 29985129)
Peschek J, Acosta-Alvear D, Mendez AS, Walter P. A conformational RNA zipper promotes intron ejection during non‐conventional XBP1 mRNA splicing. EMBO Rep 16:1688–1698, 2015 Publication identifiers: (PMID: 26483401)