Jordan Tsai

Alumni Graduate Student

Scientific Interest

When the unfolded protein response (UPR) is activated, global synthesis of proteins is shut down to stem the flux of new proteins into the endoplasmic reticulum (ER). However, during this shut down, a subset of proteins is instead preferentially translated. I am interested in studying the mechanisms by which preferential translation is achieved, and also other modes of translation regulation involved in ER stress.

Former Lab Affiliations

2010-2013

Dr. Jamie Cate – Undergraduate Researcher, University of California, Berkeley

Education

2008-2012	B.S. Chemical Biology – University of California, Berkeley, USA
2013-Present	Ph.D – University of California, San Francisco, USA

Selected Publications

Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science 364:491-495, 2019 Publication identifiers: (PMID: 31048491)
Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science 359:6383, 2018 Publication identifiers: (PMID: 29599213)
Starck SR, Tsai JC, Chen K, Shodiya M, Wang L, Yahiro K, Martins-Green M, Shastri N, Walter P. Translation from the 5’ untranslated region shapes the integrated stress response. Science 351:6272, 2016 Publication identifiers: (PMID: 26823435)
Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. Structure-activity studies of bis-O-arylglycolamides: inhibitors of the integrated stress response. Chem Med Chem 11:870-80, 2016 Publication identifiers: (PMID: 26789650)
Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez A, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. eLife 4:e07314, 2015 Publication identifiers: (PMID: 25875391)
Noriega T, Tsai A, Elvekrog M, Petrov A, Neher S, Chen J, Bradshaw N, Puglisi J, Walter P. Signal recognition particle-ribosome binding is sensitive to nascent chain length. J Biol Chem 289:19294-305, 2014 Publication identifiers: (PMID: 24808175)