Signal transduction, regulation of stress response pathways
Understanding how Ire1 activity is tuned to ER stress through oligomerization
| 2010 | – Summer AMGEN Undergraduate Researcher, Stanford University |
| 2008-2012 | BA Chemistry – Amherst College, |
| 2012-2019 | PhD – University of California, San Francisco, |
Belyy V, Zuazo-Gaztelu I, Alamban A, Ashkenazi A, Walter P. Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers. bioRxiv https://www.biorxiv.org/content/10.1101/2021.09.29.462487v1, 2021
(PMID: not available) (PDF)
Lam M, Marsters S, Ashkenazi A, Walter P. Misfolded proteins bind and activate death receptor 5 to induce apoptosis during unresolved endoplasmic reticulum stress. eLife 9:e52291, 2020
(PMID: 1904339) (PDF)
Perlaza K, Toutkoushian H, Boone M, Lam M, Iwai M, Jonikas MC, Walter P, Ramundo S. The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response. eLife 8:e49577, 2019
(PMID: 31612858) (PDF)
Lam M, Lawrence DA, Ashkenazi A, Walter P. Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress. Cell Death & Diff. 25:1530–1531, 2018
(PMID: 29991746) (PDF)