Joshua Miller
Alumni Graduate Student
Selected Publications
Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science 364:491-495, 2019
(PMID: 31048491) (PDF)
Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science 359:6383, 2018
(PMID: 29599213) (PDF)
Young J, Ursini J, Legate K, Miller J, Walter P, Andrews D. An amino-terminal domain containing hydrophobic and hydrophilic sequences binds the signal recognition particle receptor alpha subunit to the beta subunit on the endoplasmic reticulum membrane. J Biol Chem 270:15650-7, 1995
(PMID: 7797564) (PDF)
Miller J, Tajima S, Lauffer L, Walter P. The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. J Cell Biol 128:273-82, 1995
(PMID: 7844142) (PDF)
Miller J, Bernstein H, Walter P. Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor. Nature 367:657-9, 1994
(PMID: 8107852) (PDF)
Miller J, Wilhelm H, Gierasch L, Gilmore R, Walter P. GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation. Nature 366:351-4, 1993
(PMID: 8247130) (PDF)
Miller J, Walter P. A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane. Ciba Found Symp 147-59;159-63, 1993
(PMID: 8299417)