Tsan-wen Lu

Alumni Postdoctoral Fellow

Scientific Interest

Structure-function relationships in protein complex; organization and regulation of protein kinase signaling pathway

Current Research Interests

Mechanism of the IRE1 oligomerization in response to UPR

Former Lab Affiliations

2008-2012	Dr. Sheng-Hsien Chiu, National Taiwan University, Taiwan
2012-2014 2014-2020	Dr. Tao-Shih Hsieh, Institute of Cellular and Organismic Biology, Academia Sinica, Taiwan Dr. Susan Taylor, University of California, San Diego

Education

2004-2008 2008-2010	B.S. Chemistry – National Taiwan University, Taiwan M.S. Chemistry – National Taiwan University, Taiwan
2014-2020	Ph.D. Chemistry – University of California, San Diego

Selected Publications

Le Thomas A, Ferri E, Marsters S, Harnoss JM, Lawrence DA, Zuazo-Gaztelu I, Modrusan Z, Chan S, Solon M, Chalouni C, Li W, Koeppen H, Rudolph J, Wang W, Wu TD, Walter P, Ashkenazi A. Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α. Nat Comms DOI: 10.1038/s41467-021-27597-7, 2021 Publication identifiers: (PMID: not available)
Belyy V, Zuazo-Gaztelu I, Alamban A, Ashkenazi A, Walter P. Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers. bioRxiv https://www.biorxiv.org/content/10.1101/2021.09.29.462487v1, 2021 Publication identifiers: (PMID: not available)
Tran NH *, Carter SD *, De Mazière A, Ashkenazi A, Klumperman J, Walter P *, Jensen GJ *. The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes. Science 374:52-57, 2021 Publication identifiers: (PMID: 34591618)
Harnoss JM, Le Thomas A, Shemorry A, Marsters SA, Lawrence DA, Lu M, Chen Y-C A, Qing J, Totpal K, Kan D, Segal E, Merchant M, Reichelt M, Ackerly Wallweber H, Wang W, Clark K, Kaufman S, Beresini MH, Laing ST, Sandoval W, Lorenzo M, Wu J, Ly J, De Bruyn T, Heidersbach A, Haley B, Gogineni A, Weimer RM, Lee D, Braun M-G, Rudolph J, VanWyngarden MJ, Sherbenou DW, Gomez-Bougie P, Amiot M, Acosta-Alvear D, Walter P, Ashkenazi A. Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proc Natl Acad Sci 116:16420-16429, 2019 Publication identifiers: (PMID: 31371506)
Lu M, Lawrence D, Marsters S, Acosta-Alvear D, Kimmig P, Mendez A, Paton A, Paton J, Walter P, Ashkenazi A. Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis. Science 345:98-101, 2014 Publication identifiers: (PMID: 24994655)
Peluso P, Shan S, Nock S, Herschlag D, Walter P. Role of SRP RNA in the GTPase cycles of Ffh and FtsY. Biochemistry 40:15224-33, 2001 Publication identifiers: (PMID: 11735405)
Peluso P, Herschlag D, Nock S, Freymann DM, Johnson AE, Walter P. Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor. Science 288:1640-3, 2000 Publication identifiers: (PMID: 10834842)
Schmitz U, Behrens S, Freymann D, Keenan R, Lukavsky P, Walter P, James T. Structure of the phylogenetically most conserved domain of SRP RNA. RNA 5:1419-29, 1999 Publication identifiers: (PMID: 10580470)
Schmitz U, James T, Lukavsky P, Walter P. Structure of the most conserved internal loop in SRP RNA. Nat Struct Biol 6:634-8, 1999 Publication identifiers: (PMID: 10404218)