Ngoc-Han Tran

Alumni Graduate Student

Scientific Interest

I am a joint student between the Walter and Douglas labs. I am interested in exploring applications of DNA nanotechnology in structural studies of proteins in the Unfolded Protein Response (UPR).

Current Research Interests

(1) Defining oligomeric state of IRE1 using DNA origami. (2) Structural studies of the UPR effector Hac1 with electron cryo-microscopy.

Former Lab Affiliations

2010-2013	Dr. Lionel Cheruzel – Undergraduate Student, San Jose State University
2012	Dr. Iswar Hariharan – Amgen Scholars Summer Student, University of California, Berkeley

Education

2013	B.S. Biological Sciences – San Jose State University, USA
2013-Present	Ph.D. – University of California, San Francisco, USA

Selected Publications

Tran NH *, Carter SD *, De Mazière A, Ashkenazi A, Klumperman J, Walter P *, Jensen GJ *. The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes. Science 374:52-57, 2021 Publication identifiers: (PMID: 34591618)
Carter SD, Hampton CM, Langlois R, Melero R, Farino ZJ, Calderon MJ, Li W, Wallace CT, Tran NH, Grassucci RA, Siegmund SE, Pemberton J, Morgenstern TJ, Eisenman L, Aguilar JI, Greenberg NL, Levy ES, Yi E, Mitchell WG, Rice WJ, Wigge C, Pilli J, George EW, Aslanoglou D, Courel M, Freyberg RJ, Javitch JA, Wills ZP, Area-Gomez E, Shiva S, Bartolini F, Volchuk A, Murray SA, Aridor M, Fish KN, Walter P, Balla T, Fass D, Wolf SG, Watkins SC, Carazo JM, Jensen GJ, Frank J, Freyberg Z. Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells. Sci Adv 6:eaay9572, 2020 Publication identifiers: (PMID: 32270040)
Belyy V, Tran NH, Walter P. Quantitative microscopy reveals dynamics and fate of clustered IRE1α. Proc Natl Acad Sci 117:1533-1542, 2020 Publication identifiers: (PMID: 31871156)