BiP is the predominant DnaK/Hsp70-type chaperone protein in the ER. It is required for folding and assembling newly synthesized ER client proteins, yet having too much BiP inhibits folding. In this issue, Chambers et al. (2012. J. Cell Biol. doi:10.1083/jcb.201202005) report that ADP ribosylation of BiP provides a reversible switch that fine tunes BiP activity according to need.
A first line of defense against ER stress.
Pincus D, Walter P. A first line of defense against ER stress. J Cell Biol 198:277-9, 2012
(PMCID : PMC3413362) (PMID : 22869593) (PDF)
(PMCID : PMC3413362) (PMID : 22869593) (PDF)