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Aditya Anand

September 9, 2015 By

AdityaAnand_CV

Scientific Interest:

Proteins execute a vast array of cellular functions from cell signaling to ion transport to structural support.  To carry out these tasks, proteins adopt unique shapes in a process called protein folding. When proteins lose their shape, or “unfold”, they fail to function correctly and can further cause other proteins to unfold. A signaling network known as the integrated stress response (ISR) protects cells under these conditions by triggering a shut down of global protein synthesis. This pause in the production of proteins allows cells time and resources to mitigate protein unfolding-induced stress and prevent plaque-like aggregation. While great strides have been made in characterizing the ISR, there is more to be learned about stress responses and translational control. I am interested in furthering our mechanistic knowledge of the ISR and parallel pathways that regulate the synthesis of new proteins.

Current research interest:

Recently a small molecule modulator of the ISR called ISRIB (integrated stress response inhibitor) was discovered in our lab. My work is focused on determining a mechanism of action for this compound that can explain its blunting effects on the ISR.

Former Lab Affiliations

2010-2013 Dr. John Tainer , Lawrence Berkeley National Laboratory

Education

2007-2011 BA Molecular and Cell Biology, University of California, Berkeley
2011-Present PhD Biochemistry, University of California, San Francisco

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Karina Perlaza

September 9, 2015 By


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Niv Dobzinski

July 7, 2015 By

Scientific Interest

Understanding protein quality control mechanism and stress response in cells.

Current Research Interests

Dissecting the ATF6 Branch of the Unfolded Protein Response.

Former Lab Affiliations

2007-2009 Prof. Yuval Eshed – Master Student, Weizmann Institute of Science.

2010-2014 Prof. Jeffrey Gerst – Ph.D Student, Weizmann Institute of Science.

Education

2004-2007 B.Sc. Biology – Tel-Aviv University, Israel.

2007-2009 M.Sc. Biology – Weizmann Institute of Science, Israel.

2010-2014 Ph.D. Biology – Weizmann Institute of Science, Israel.

 

 


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Tenzin Kundron

July 1, 2015 By


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Paige Nittler

July 1, 2015 By


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