Ire1 is a signal transduction protein in the endoplasmic reticulum (ER) membrane that serves to adjust the protein-folding capacity of the ER according to the needs of the cell. Ire1 signals, in a transcriptional program, the unfolded protein response (UPR) via the coordinated action of its protein kinase and RNase domains. In this study, we investigated how the binding of cofactors to the kinase domain of Ire1 modulates its RNase activity.
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1.
Korennykh A, Egea P, Korostelev A, Finer-Moore J, Stroud R, Zhang C, Shokat K, Walter P. Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol 9:48, 2011
(PMID : 21729334) (PDF)
(PMID : 21729334) (PDF)